White Coats – DNA – Gene Testing – Lab Instrument Dream – 03 -06 -2025

Here is last night’s dream.

It opens in an ethereal very white laboratory setting in which there are no walls. There are people milling about in white laboratory coats. Most of these are young. Some have pencils and pens in the coat pocket. There is a prevalence of spectacles. I am sat at a large white desk upon which are computer terminals linked into the DNA sequencer machines. I am with two younger women both wearing white lab coats, neither of which are done up. They have name-identity-security cards on deep blue lanyards around their necks. One is blond the other dark haired. They are younger than me and “official”. I am dressed in civvies, black jeans and a black cashmere jumper. My hair has a fresh buzz-cut.

The dark haired woman asks me how the genetic testing was authorised. I explain that my haemoglobin levels are high and that I have a large excess of ferritin in my blood. She nods and gestures for me to open the files on the computer in front of me. These files contain my full DNA results and parts where the study has zoomed into specific genes of concern regarding my blood and health. Before we get to the results there is a screen showing who has accessed these files. There is a list of health professionals in normal black type. Then in a box ringed in bright red and backlit is one saying D. Someone who I once was acquainted with. The files access log says that he has accessed these files illegally and without proper authorisation on a number of occasions. He has been illegally monitoring my test results. The woman asks me if I know who it is. Yes. Somehow, he has contrived illegal access. He has been snooping on my genetic testing and passing them on. It is illegal, he has been unlawful.

The scene changes to an ultramodern biochemistry laboratory on an upper floor. There are wet benches, fume hoods and instrumentation suites. Everybody apart from me is decked out in white lab coats. They are all younger than me and exude and air of quite professionalism going about their business. I enter a glass doored laboratory instrumentation suite. At the “welcome” desk there is a young man and a young woman. He asks how he might help. I explain that I need to run a sample. He shows me into to their latest machine. It is a hybrid mass spectrometer-NMR- separation machine. They are convinced that I know little to nothing about science instruments and mass spectrometry in particular. I say that before I run my sample, I need to assess the signal to noise ratio of the instrument. I inspect it.

When I am ready, I inject my sample using a micro-litre syringe into the septum at the spectrometer inlet. The results will be available in a few hours. Everyone thinks that I am a pleb, who knows nothing. The next day I return and ask to run the sample again. I have left it on the bench to oxidise overnight and that will give me an added insight into the chemical composition. The man is a bit reluctant but lets me run the sample again.

The dream ends.

Bioethics, Genetic Testing and Notification

This morning, just for a change, we went to another hospital for a genetics follow up to the wife’s breast cancer. In France they are very keen on prophylactic measures and like to test things in a lab wherever possible. The wife’s blood is going to be screened for genetic predisposition to breast and ovarian cancer. The results will have implications for her and her siblings, including the men. In French law the geneticist or the wife herself MUST inform her brother if the tests suggest that he too might have a predisposition for cancer. This true for if he lived in France not sure if it extends legally to the UK. The form letter on the government site, for the geneticist to fill in, does not really hide the identity of the provider of genetic material very well. Today she advised against sending this. It was better to pass on the tidings of joy personally.


« Décret n° 2013-527 du 20 juin 2013 relatif aux conditions de mise en œuvre de l’information de la parentèle dans le cadre d’un examen des caractéristiques génétiques à finalité médicale.

Notice : la loi no 2011-814 du 7 juillet 2011 relative à la bioéthique a modifié le dispositif d’information de la parentèle dans le cadre d’un examen des caractéristiques génétiques introduit par la loi no 2004-800 du 6 août 2004 relative à la bioéthique. La personne concernée est informée, avant la réalisation de l’examen de ses caractéristiques génétiques, de l’obligation qui pèse sur elle, au cas où une anomalie génétique grave serait diagnostiquée, d’informer les membres de sa famille potentiellement concernés dès lors que des mesures de prévention ou de soins peuvent leur être proposées. »


The gastroenterologist following my colon cancer has been very pushy about me notifying blood relatives because there is some genetic component to colon cancer.

I have already tested for HBA B27 which was negative therefore there are no requirements for notification. There are no possible interventions foreseen.

I am considering HFE and JAK poly screening, the latter of which costs ~€1500. The HFE if positive would indicate hereditary Haemochromatosis which can have interventions. The JAK poly screening for predisposition to malignancies, would if positive, require notification. There would under law be an obligation to inform.

This explains why the GP isn’t overly keen. There is a possible can of worms attached.

The documentation for the test today has inherent in it an authorisation to share genetic test results with relatives if relevant to their healthcare.

Given the price of the test, I am likely to need a specialist to write the JAK screening prescription. They may well want a “who do you think you are” family tree.

You learn something every day…and given the French love of protocol this is non-negotiable.

There are often implications we do not consider…and only find subsequently.

Once you have had test results you cannot un-have them or un-see them…

Hmnn…