Prompted by the dream the other day I have been having a little look into neuroscience. It seems that there is much interest in using hallucinogens to {perhaps} help with mental health. There is interest in the crossover between dreams and hallucinogenic activity. This from “Frontiers in Neuroscience”.

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In the books of Castaneda, don Juan introduces him to peyote (lophophora williamsii), jimson weed (datura) and magic mushrooms (psylocibin). Castaneda describes some of his outlandish experiences whilst off his trolly. Castaneda wrote a book on “The Art of Dreaming” which perhaps tacitly lies aback much of the Lucid Dreaming genre. One could suggest that Castaneda had an effect on neuroscience and the psychology of dreams. If you look at the graph below from the above article the similarity of psychoactive experience and dream lucidity is correlated with the don Juan substances of choice. Only LSD outperforms the “natural” substances. Cannabis comes close. {Man}

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When I was ill, I was prescribed the MAOI phenelzine which had no psychoactive effects, as far as I could tell. I had one hypertensive crisis at a business dinner in Japan, something iffy with tryamine in the seaweed. Those Nitrogen atoms look receptor ready…hydrogen bonding to the fore.

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“Phenelzine, sold under the brand name Nardil among others, is a non-selective and irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine family which is primarily used as an antidepressant and anxiolytic to treat depression and anxiety. Along with tranylcypromine and isocarboxazid, phenelzine is one of the few non-selective and irreversible MAOIs still in widespread clinical use.”

I used this for probably one year. It is a MAOI to the right of the graph.

I have had limited exposure to magic mushrooms and LSD, over thirty years ago and I stopped smoking week in 1999.

Obviously if one is doing research, it must seem pukka and thoroughly scientific. I doubt anyone acknowledges Castaneda though some may have read him…