What is Safe to Ignore?

The ongoing foray into medical things has thrown up a few things which may or may not be safe to ignore. As a part of the ongoing saga I am going to have a full cardiovascular MOT or road worthiness test. The presence of excess iron has many knock on implications and I have already been prescribed one medication which is no longer recommended.

You can call me rusty.

It is a long old haul and the garden is suffering a bit from lack of attention.

It seems so far that the Jury has decided that I don’t have five of the genetic mutations which I have tested for. I am going to discuss these further, a little. My status as a mutant has not yet been confirmed.

Traditional western medicine is based upon symptoms. By the time symptoms are apparent disease has arrived. More recently tests are done with a mind to early prophylaxis where possible. What may be, is clear in some case and less so in others. The UK mass newspapers are full of misdiagnosis horror stories.

“I went to see multiple GPs. They sent me home with a box of Rennie’s. Later in A&E after I tripped up on the way home from the pub, they found a basketball size alien tumour of extraplanetary origin growing in my kidney. I have two and half weeks to live!”

These cases are rare and anomalous. The tendency is to discount and not pay sufficient attention to things which do not fit your story, your view of how things might be.

“It is impossible to have extra planetary tumours growing in the kidneys. They are usually found in the spleen!! Everyone knows this! DOH.”

People can be very dismissive about things which later turn out to be highly important. They ignore things which are not safe to ignore.

I like to offer people options. The easiest option is that I am an eccentric borderline nut-job burn out. I suspect that as an explanation this would find purchase in the minds of many. It is a pigeonhole into which I can be fitted easily. I can then be ignored. I may be briefly entertained but never taken seriously. To develop this a little further. If one is enamoured with intrigue, one could say that whacko-nut-job-eccentric is my cover.

With a high degree of certainty one can predict answers to certain questions. This is because denial is a Pavlovian response in some. I have asked a number of people if they feel they have unresolved karma with me. To date no-body has answered that question. Nobody has tried. They have ignored it and let it drop. It is easy to discard and discount. On my part it has been a genuine and well-intended question very largely for their benefit. But of course people know best and are unwilling to do the work needed to answer a question of moderate depth and wide implication. People want to preserve face above all else. FOLOF, fear of loss of face.

Is such a question safe to ignore?

In the “normal” world and within its confines and rules, yes. But this is a world and philosophy bridging question and the limited “normal” context loses its imagined wide applicability. Ignoring such a question ignores and devalues a way of being held by hundreds of millions of people.

A lot of people think small details can be ignored. A prime minister preaching about lock down may deem it his God-given right to party. Ignoring, conveniently, the detail which he said that we didn’t ought. A small detail ignored can come back to bite you on the bum with rabid and perhaps gangrenous teeth.

“The law was not broken in its strictest and most convenient {for us} interpretation.”

Obsessing about detail can be very tiring. So knowing what is and is not important makes life easier. We all make choices and assign priorities whether consciously or by default.

People may argue the toss when it is very unwise so to do. The toss once argued for cannot be u-turned always. You may have won the toss but you can be up shit creek in a barbed wire canoe without a paddle. The toss will not keep you warm in a nuclear winter.

My own opinion is that it is not safe to ignore your dreams. Experimental evidence has suggested this to me. This morning’s dream had someone I once knew trying to manipulate a situation, to find some kind of pretext. It was suggested that some kind of trap is in preparation. It revolves around the number of conspiracy three, three people. In every conspiracy there has to be at least three. Without being paranoid I am opening myself up to the dream both at night and during the day to see what, if anything, the dreaming has to add to this morning’s dream.

It is very easy to imagine important and significant the wrong things entirely.

We can ignore the things we did not ought to. We may need to pay strict attention and focus to things which we might otherwise flippantly ignore.

What is safe to ignore?

Genetic Counsellors and Cans of Worms

I learned a new phrase today “genetic counsellor”. Apparently, at least in Canada, such things exist. I have been recommended to have the HFE gene test to see if I have hereditary haemochromatosis (HH). This for completion. Back in 1994 I visited this high haemoglobin “space” and was bled regularly at St Thomas’. Retrospect suggests that I may have had an ongoing health condition which was missed back then.

They took an armful each time. 

This HFE mutation would provide a benign explanation for my raised haem and ferritin levels. My ferritin levels have been increasing with time over the last four years. I don’t really have many of the symptoms associated with the genetic disease. It is linked with the less benign polycythaemia. Which would require a wider more substantive gene panel test, so-called molecular oncology. The authorisation for this testing is probably reserved for specialists. Iron overload is not without consequences. It can “cause” cancer or be correlated with it. Medical literature often blurs correlation with cause.

The problem with all this new-fangled gene testing is that it can open a can of worms

Needless to say, the genetics are complex.

I would be a mutant of sorts…

The next stages are Iron MRI and/or liver biopsy. The latter does not sound like much fun!!

Liver disease is possible maybe even likely, but I am largely asymptomatic. My enzyme work was ok.

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The next stage of inquiry would be to look for myeloproliferative neoplasms which are rare, not lottery winning rare, but rare enough. Search of JAK 2 and other related things starts increasing the price. JAK 2 can mutate.

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Mutations in JAK2 have been implicated in polycythemia vera, essential thrombocythemia, and myelofibrosis as well as other myeloproliferative disorders. This mutation (V617F), a change of valine to phenylalanine at the 617 position, appears to render hematopoietic cells more sensitive to growth factors such as erythropoietin and thrombopoietin, because the receptors for these growth factors require JAK2 for signal transduction. JAK2 mutation, when demonstrable, is one of the methods of diagnosing polycythemia vera.”

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The thing is looking closely at most people my age the chances are that you will find something which has gone wrong.

The French sites suggest that some kind of follow up is warranted because of my Iron status.

Not sure what if anything the GP will recommend….

The osteoporosis situation seems simpler to treat with some pills, supplements and vitamins. But could have an Iron cause.

Given that the haemoglobin situation has been ongoing for, perhaps, thirty years it seems unlikely that any new unpleasant things have suddenly taken hold. But the ferritin level has doubled since 2021.

There is part of me that thinks that I just let this all drop…The osteoporosis might have enabled the fracture of my femoral neck six years ago. I have perhaps been living with it since. Simple answer is to not fall over.

A few more pills is no big deal however…

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hereditary haemochromatosis – regularly being bled.

Not HH – Iron MRI / Liver biopsy —

Liver disease – it depends on what – treatments in absence of virus are usually diet and no booze.

Something fancy and esoteric – myeloproliferative neoplasms – massive complex can of worms

The French sites suggest that some kind of follow up is warranted because of my Iron status.

What is inside the can…?